Reaction #156637

ord-6ce94083da4b4bdb958278a383b4a0fc

Reaction equation

CCCCOc1ccc2c(c1)CCN(c1ccc(Br)cc1)C2=O
2-(4-bromophenyl)-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one
CN(C)[C@@H]1CCNC1
dimethyl-(R)-pyrrolidin-3-yl-amine
→
CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](N(C)C)C3)cc1)C2=O
6-Butoxy-2-[4-((R)-3-dimethylamino-pyrrolidin-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Reactants

CCCCOc1ccc2c(c1)CCN(c1ccc(Br)cc1)C2=O
2-(4-bromophenyl)-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one
CN(C)[C@@H]1CCNC1
dimethyl-(R)-pyrrolidin-3-yl-amine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherIn this way the product was obtained with molecular weight 407.56 (C25H33N3O2)

Procedure

According to Method R, 2-(4-bromophenyl)-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one was reacted with dimethyl-(R)-pyrrolidin-3-yl-amine. In this way the product was obtained with molecular weight 407.56 (C25H33N3O2); MS (ESI): 408 (M+H+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09