Reaction #156593

ord-575e3cc6f39447a2bf39d20582648f94

Reaction equation

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](NC)C3)c(F)c1)C2=O
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
CC(C)=O
acetone
→
CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](N(C)C(C)C)C3)c(F)c1)C2=O
6-Butoxy-2-{3-fluoro-4-[(R)-3-(isopropylmethylamino)pyrrolidin-1-yl]phenyl}-3,4-dihydro-2H-isoquinolin-1-one

Reactants

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](NC)C3)c(F)c1)C2=O
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
CC(C)=O
acetone

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe product with the molecular weight of 453.61 (C27H36FN3O2) was obtained in this way

Procedure

6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one (hydrochloride) was reductively alkylated with acetone by method J. The product with the molecular weight of 453.61 (C27H36FN3O2) was obtained in this way; MS (ESI): 454 (M+H+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822495B2uspto-grants-2014_09