Reaction #1563957

ord-e16f05c112534780aad310b0466be754

Reaction equation

Cl.Fc1ccc(F)c([C@H]2C[C@H](F)CN2)c1
(2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidine hydrochloride
CCOC(=O)c1cnn2ccc(Br)cc12
Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate
→
CCOC(=O)c1cnn2ccc(N3C[C@@H](F)C[C@@H]3c3cc(F)ccc3F)cc12
title compound
CCOC(=O)c1cnn2ccc(N3C[C@@H](F)C[C@@H]3c3cc(F)ccc3F)cc12
Ethyl 5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Reactants

Cl.Fc1ccc(F)c([C@H]2C[C@H](F)CN2)c1
(2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidine hydrochloride
CCOC(=O)c1cnn2ccc(Br)cc12
Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherto afford as yellow solid

Procedure

The title compound (Int-67) was prepared by the method similar to that for Int-84 using (2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidine hydrochloride (Int-47) and Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate to afford as yellow solid. LCMS (ESI): m/z 390.8 (M+H).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09402833B2uspto-grants-2016_08