Reaction #1563934

Reaction equation

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

Yield 79.8%

2-(2,5-difluorophenyl)pyrrolidine

Yield 79.8%

Solvents

MeOH H2O

Conditions

Workup

1. 1
   OtherThe reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   Extractionextracted with DCM
3. 3
   Dryingdried over anhydrous sodium sulphate
4. 4
   Concentrationconcentrated under reduced pressure

Procedure

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

Source