Reaction #155407

ord-93a3b2b663214d489cd4f62b05f10f19

Reaction equation

CC(C)(C)OC(=O)N1CC(=O)C1
N-Boc-3-azetidinone
NCCO
ethanolamine
→
CC(C)(C)OC(=O)N1CC(NCCO)C1
N—(N-Boc-azetidin-3-yl)-2-amino-ethanol
Yield 62.3%

Reactants

CC(C)(C)OC(=O)N1CC(=O)C1
N-Boc-3-azetidinone
NCCO
ethanolamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

N-Boc-3-azetidinone (1.0 g, 5.84 mmol) was treated with ethanolamine following Procedure 1-Method A to yield N—(N-Boc-azetidin-3-yl)-2-amino-ethanol (0.75 g, 3.46 mmol, 62.3% yield): MS m/e [M+H]+ calcd 217.1. found 217.2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822424B2uspto-grants-2014_09