Reaction #155379

ord-e5cb8d78f176464f9c29e2d601fe3958

Reaction equation

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Mannitol
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
Oxycodone

Reactants

—
PoloXamer 407
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Mannitol

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The active plug comprised: Oxycodone hydrochloride, PEO 200 000, Mannitol, PoloXamer 407, which were mixed. Afterwards the powder mixture fed to the injection moulding machine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08821928B2uspto-grants-2014_09