Reaction #155319

Reaction equation

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

Yield 87.6%

Solvents

dichloromethane

Conditions

Workup

1. 1
   Otherfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   OtherThe catalyst was removed by celite filtration
3. 3
   Othercondensed under reduced pressure
4. 4
   Dryingdried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated to dryness under reduced pressure

Procedure

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Source