Reaction #1552050

Reaction equation

1,8-octanediamine

triethylamine

furoyl chloride

→

N,N′-(octane-1,8-diyl)bis(furan-2-carboxamide)

Conditions

Workup

1. 1
   OtherThe resulting compound was purified by column chromatography (98:2 DCM:EtOAc)
2. 2
   Otherthe product obtained as a white solid (21.5 g/92%)

Procedure

The general procedure was carried out using 1,8-octanediamine (10.0 g, 69.3 mmol), triethylamine (14.2 g, 141 mmol), DMAP (0.17 g, 1.35 mmol) and furoyl chloride (19.0 g, 146 mmol). The resulting compound was purified by column chromatography (98:2 DCM:EtOAc), and the product obtained as a white solid (21.5 g/92%).

Source