Reaction #1524

Reaction equation

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

Conditions

Workup

1. 1
   OtherAfter completion of the reaction
2. 2
   Extractionthe resultant mixture was extracted with ether
3. 3
   Washwashed with water, which
4. 4
   Washwas further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   Washwashed again with water
7. 7
   ConcentrationThe reaction product was concentrated
8. 8
   Otherseparated by colomun chromatography

Procedure

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

Source