Reaction #1519107

Reaction equation

ammonium chloride

4-chloro-2-cyanopyridine

sodium methoxide

→

2-amidino-4-chloropyridine hydrochloride

Solvents

methanol

Conditions

Workup

1. 1
   Temperaturerefluxing
2. 2
   OtherThe volatile components are then removed in vacuo

Procedure

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

Source