Reaction #1509647

Reaction equation

1,1,1-tris(hydroxymethyl)ethane

2,2-dimethoxypropane

sulfuric acid

→

(1,4,4-trimethyl-3,5-dioxanyl)methane-1-ol

Yield 72.0%

Solvents

acetone

Conditions

Workup

1. 1
   Otherwas changed back to a room temperature
2. 2
   workup.STIRRINGthe mixture was stirred for 2 hours
3. 3
   workup.DISTILLATIONAfter acetone was distilled off
4. 4
   Othera fraction obtained at 70° C. under reduced pressure (1.7 mmHg)
5. 5
   Otherwas collected

Procedure

In a three-necked flaks, 1,1,1-tris(hydroxymethyl)ethane (200 g) and 2,2-dimethoxypropane (260 g) were suspended in acetone (150 g), one droplet of concentrated sulfuric acid was added thereto at 0° C., and then the mixture was stirred for 2 hours. The temperature was changed back to a room temperature, and the mixture was stirred for 2 hours. After acetone was distilled off, a fraction obtained at 70° C. under reduced pressure (1.7 mmHg) was collected to obtain (1,4,4-trimethyl-3,5-dioxanyl)methane-1-ol (192 g).

Source