Reaction #1509625

Reaction equation

2,2,2-trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)-ethanone

2-trichloroacetyl-1-methylpyrrole

4-(2-amino-1H-imidazol-4-yl)-N-dodecyl-butyramide hydrochloride

→

title compound 14

Yield 96.0%

2,2,2-trichloro-1-(4,5-dibromo-1-methyl-pyrrol-2-yl)-ethanone

Yield 96.0%

Conditions

Procedure

Using the same general procedure as used for the synthesis of 2,2,2-trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)-ethanone 8, 5.00 g of 2-trichloroacetyl-1-methylpyrrole 12 gave 8.14 g (96%) of the title compound 14 as white needles. 1H NMR (300 MHz, DMSO-d6) δ 7.60 (s, 1H), 3.96 (s, 3H); 13C NMR (100 MHz, DMSO-d6) δ 170.86, 123.81, 122.68, 120.58, 99.58, 94.89, 37.60; HRMS (FAB) calcd for C7H4Br2Cl3NO (M+) 380.7725, found 380.7744.

Source