Reaction #1509583

Reaction equation

3-Nitro-benzyl-amine

cyclohexyl isocyanate

→

1-Cyclohexyl-3-(3-nitro-benzyl)-urea

Solvents

THF

Conditions

Workup

1. 1
   Filtrationwas filtered off
2. 2
   Washwashed with diethyl ether
3. 3
   workup.ADDITIONtreated with 5% aqueous NH4OH
4. 4
   FiltrationAfter filtering
5. 5
   Dryingdrying the title compound
6. 6
   Otherwas isolated (4.5 g, FP 168-169° C.)

Procedure

3-Nitro-benzyl-amine (5 g) was suspended in THF (130 ml) and cyclohexyl isocyanate (7 ml) was added dropwise at 25° C. After stirring for 2 h the resulting precipitate was filtered off, washed with diethyl ether and treated with 5% aqueous NH4OH. After filtering and drying the title compound was isolated (4.5 g, FP 168-169° C.)

Source