Reaction #1509579

Reaction equation

sodium acetate

4-methyl-3-oxo-pentanoic acid ethyl ester

Bromine

→

Ethyl 2-bromo-4-methyl-3-oxopentanoate

Solvents

acetic acid

Conditions

Workup

1. 1
   Temperatureto warm to room temperature
2. 2
   Concentrationwas concentrated in vacuum
3. 3
   Otheraffording 3.8 g crude ethyl product which

Procedure

To a suspension of sodium acetate (1.9 g) in glacial acetic acid (15 ml) was added 4-methyl-3-oxo-pentanoic acid ethyl ester (2 g) and the reaction mixture cooled to 10° C. Bromine (0.7 ml) was then added dropwise. The resulting solution was allowed to warm to room temperature and stirred for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum affording 3.8 g crude ethyl product which was used directly in the next synthetic step.

Source