Reaction #1503910

Reaction equation

5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

cyclohexanol

HCl

→

title compound

5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(cyclohexyl) ester hydrochloride salt

Conditions

Procedure

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and cyclohexanol according to the procedure of Example 1 as a yellow gum: 1H NMR (300 MHz, CDCl3): δ 1.10-1.40 (complex m, 7H), 1.45-1.60 (brm, 4H), 1.63-1.81 (brm, 8H), 1.82-1.95 (brm, 4H), 2.72-2.90 (brm, 1H), 3.10-3.30 (brm, 2H), 3.37-3.55 (m, 2H), 4.90-5.03 (m, 2H), 5.37-5.52 (brs, 1H), 6.71-6.90 (complex m, 4H), 7.20-7.32 (m, 2H), 7.44 (s, 1H), 8.55-8.80 (brs, 1H), 9.90-10.20 (brs, 1H); MS (ES) m/z (relative intensity): 585 (M+ -HCl), 532 (10).

Source