Reaction #1470425

Reaction equation

1-oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine

diethanolamine

→

title compound

Yield 29.9%

1-Oxyl-2,2,6,6-tetramethyl-4-{2-hydroxy-3-[di(2-hydroxyethyl)amino]propoxy}piperidine

Yield 29.9%

Solvents

water

Conditions

Workup

1. 1
   ExtractionThe solution is then extracted with methylene chloride
2. 2
   ExtractionThe methylene chloride extract
3. 3
   Dryingis dried over anhydrous magnesium sulfate
4. 4
   Filtrationfilter
5. 5
   Concentrationconcentrated
6. 6
   OtherThe crude reaction product
7. 7
   Otheris purified by column chromatography

Procedure

A solution of 2.28 g (0.01 mol) of 1-oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine and 1.05 g (0.01 mol) of diethanolamine in 25 mL of water is stirred at ambient temperature for 16 hours. The solution is then extracted with methylene chloride. The methylene chloride extract is dried over anhydrous magnesium sulfate, filter and concentrated. The crude reaction product is purified by column chromatography to afford 1.0 g of the title compound as a red oil.

Source