Reaction #1470424

Reaction equation

1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine

epichlorohydrin

→

title compound

1-Oxyl-2,2,6,6-tetramethyl-4-glycidyloxypiperidine

Solvents

sodium hydroxide

toluene

Conditions

Workup

1. 1
   Otheris reacted together
2. 2
   DryingThe organic phase is dried over anhydrous magnesium sulfate
3. 3
   Concentrationconcentrated

Procedure

A vigorously stirred two phase solution of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine, epichlorohydrin, tetrabutylammonium bromide in 50% aqueous sodium hydroxide and toluene is reacted together. The organic phase is dried over anhydrous magnesium sulfate and concentrated to yield the title compound as a low melting red solid after column chromatography.

Source