Reaction #1451533

ord-4d4d2198be254cd8b88c1bb7b54de9c9

Reaction equation

CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C
compound
CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C
tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate
CC(C)(C)OC(=O)CN.Cl
glycine tert-butyl ester hydrochloride
CC(C)(C)OC(=O)C1(N)C=CC=C(N)C1
1-(tert-butoxycarbonyl)-1,3-phenylenediamine
→
CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(N)c1
title compound
CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(N)c1
N-{(1R)-1-[(3-aminoanilino)carbonyl]propyl}-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide

Reactants

CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C
compound
CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C
tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate
CC(C)(C)OC(=O)CN.Cl
glycine tert-butyl ester hydrochloride
CC(C)(C)OC(=O)C1(N)C=CC=C(N)C1
1-(tert-butoxycarbonyl)-1,3-phenylenediamine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, 1-(tert-butoxycarbonyl)-1,3-phenylenediamine was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07888348B2uspto-grants-2011_02