Reaction #1447091

Reaction equation

N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester

hydrochloric acid

→

title compound

(3,4,5-trifluoro)-D,L-Phenylalanine hydrochloride

Solvents

water

Conditions

Workup

1. 1
   TemperatureThe mixture was heated
2. 2
   Temperatureat reflux for 4 hrs
3. 3
   Otherevaporated to dryness
4. 4
   OtherThe residue was triturated with diethyl ether (4×20 mL)
5. 5
   FiltrationThe solid was filtered
6. 6
   Otherdried

Procedure

N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester (1.33 g, 3.2 mmol) was suspended in water (15 mL) at 25° C. and treated with conc. hydrochloric acid (5 mL). The mixture was heated at reflux for 4 hrs and evaporated to dryness. The residue was triturated with diethyl ether (4×20 mL). The solid was filtered and dried to afford title compound (0.72 g)

Source