Reaction #1442511

Reaction equation

2-(3,5-dimethylphenoxy)acetic acid

ammonia

→

4,6-dimethyl-3-benzofuranone

Yield 100.0%

Conditions

Workup

1. 1
   workup.ADDITIONThe mix was poured in ice
2. 2
   Otherwas obtained
3. 3
   ExtractionThe mix was extracted with methylenechloride
4. 4
   workup.ADDITIONthe organic phase was treated with a solution of bicarbonate

Procedure

A mix of polyphosphoric acid and 2-(3,5-dimethylphenoxy)acetic acid was heated at 50° C. for 8 hours. The mix was poured in ice, treated with ammonia until a pH 7 was obtained. The mix was extracted with methylenechloride and the organic phase was treated with a solution of bicarbonate, made anhydrous (Na2SO4) and freed from the solvent under reduced pressure, to produce 4,6-dimethyl-3-benzofuranone (40% conversion, 100% yield).

Source