Reaction #1442502

Reaction equation

example 1

3-(4,4-dimethyl-2,6dioxocylohex-1-ylideneethyl)amino-2-(Fluorenylmethyloxycarbonyl)amino-propionic Acid

piperidine

→

2-Amino-3-(4,4-dimethyl-2,6-dioxocylohex-1-ylideneethyl)amino-propionic Acid

Solvents

DMF

DMF

Conditions

Workup

1. 1
   OtherThe resin prepared
2. 2
   Filtrationfiltered
3. 3
   workup.ADDITIONAnother 40 mL portion of 20% piperidine in DMF was added to the resin
4. 4
   FiltrationThe resin was filtered
5. 5
   Washwashed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL)
6. 6
   OtherThe resin was dried in vacuo

Procedure

The resin prepared according to example 1 (7.085 g) in DMF was treated with 20% piperidine in DMF (40 mL) for 10 min and filtered. Another 40 mL portion of 20% piperidine in DMF was added to the resin and shaken at room temperature for 20 min. The resin was filtered and washed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL). The resin was dried in vacuo.

Source