Reaction #1435728

Reaction equation

diethyl (2-chloro-6-fluorophenyl)malonate

aminoimidazole hydrochloride

1,5-diazabicyclo[4.3.0]-5-nonene

→

5,7-dihydroxy-6-(2-chloro-6-fluorophenyl)imidazo[1,2-a]pyrimidine DBN

Yield 44.5%

Solvents

N,N-dimethylformamide

Conditions

Workup

1. 1
   Temperatureto cool
2. 2
   Filtrationfiltered the precipitate
3. 3
   Otherdried

Procedure

A mixture of 2.89 g of diethyl (2-chloro-6-fluorophenyl)malonate, 1.20 g of aminoimidazole hydrochloride, 2.48 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 10 ml of N,N-dimethylformamide (DMF) was heated at 100° C. for 4 hours. The reaction mixture was allowed to cool, filtered the precipitate and dried to give 1.80 g of 5,7-dihydroxy-6-(2-chloro-6-fluorophenyl)imidazo[1,2-a]pyrimidine DBN salt.

Source