Reaction #1379887

Reaction equation

2-chloro-3-nitro-6-methoxypyridine

bis(2-methoxyethyl)amine

→

yellow powder

Yield 90.6%

bis(2-methoxyethyl)(6-methoxy-3-nitro-2-pyridyl)amine

Yield 90.6%

Solvents

ethanol

Conditions

Workup

1. 1
   TemperatureThe mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   OtherThe precipitate formed
4. 4
   Filtrationis filtered off by suction
5. 5
   Otherdried under vacuum to constant weight

Procedure

4 g (0.0212 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 50 ml of ethanol and 6.32 ml (0.0424 mol) of bis(2-methoxyethyl)amine are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 5.47 g of yellow powder are obtained, ie a yield of 90.6%.

Source