Reaction #1379885

Reaction equation

diethanolamine

2-chloro-3-nitro-6-methoxypyridine

dioxane

→

yellow powder

Yield 74.0%

2-[(2-hydroxyethyl)(6-methoxy-3-nitro-2-pyridyl)amino]ethanol

Yield 74.0%

Solvents

water

Conditions

Workup

1. 1
   TemperatureThe mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   OtherThe precipitate formed
4. 4
   Filtrationis filtered off by suction
5. 5
   Otherdried

Procedure

1.9 g (0.01 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 30 ml of dioxane, 5 ml of water and 2.1 ml (0.02 mol) of diethanolamine are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried. 1.9 g of yellow powder are obtained, ie a yield of 74%.

Source