Reaction #1379883

Reaction equation

2-methylaminoethanol

2-chloro-3-nitro-6-methoxypyridine

dioxane

→

yellow powder

Yield 70.0%

2-[(6-methoxy-3-nitro-2-pyridyl)methylamino]ethanol

Yield 70.0%

Solvents

water

Conditions

Workup

1. 1
   TemperatureThe mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   OtherThe precipitate formed
4. 4
   Filtrationis filtered off by suction
5. 5
   Otherdried under vacuum to constant weight

Procedure

1.9 g (0.01 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 30 ml of dioxane, 5 ml of water and 1.6 ml (0.02 mol) of 2-methylaminoethanol are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 1.6 g of yellow powder are obtained, ie a yield of 70%.

Source