Reaction #1371

Reaction equation

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

Yield 82.6%

Solvents

water

Conditions

Workup

1. 1
   Temperaturethe mixture is refluxed for 2.5 hours
2. 2
   TemperatureAfter cooling
3. 3
   Extractionthe resultant is extracted with diethyl ether
4. 4
   Dryingthe extract is dried over magnesium sulfate
5. 5
   Concentrationconcentrated

Procedure

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

Source