Reaction #1367

Reaction equation

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

Yield 71.3%

Solvents

ethanol

Conditions

Workup

1. 1
   FiltrationAfter the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   Extractionextracted with dichloromethane
4. 4
   DryingThe is dried over magnesium sulfate
5. 5
   Concentrationconcentrated

Procedure

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

Source