Reaction #1340578

Reaction equation

octadecenyl succinic anhydride

ethanolamine

→

N-(2-hydroxyethyl)-9-octadecenyl succinimide

Yield 75.3%

Conditions

Workup

1. 1
   OtherA 50 mL reaction flask
2. 2
   Otherthe resulting mixture was reacted at 110° C. for 6 hours under continuous nitrogen purging and with vigorous stirring
3. 3
   OtherThe reaction product was purified by silica gel column chromatography (mobile phase: ethyl acetate/hexane)

Procedure

A 50 mL reaction flask was charged with 35.1 g of octadecenyl succinic anhydride (manufactured by Tokyo Chemical Industry Co., Ltd.) and 6.1 g of ethanolamine (manufactured by Tokyo Chemical Industry Co., Ltd.), and the resulting mixture was reacted at 110° C. for 6 hours under continuous nitrogen purging and with vigorous stirring. The reaction product was purified by silica gel column chromatography (mobile phase: ethyl acetate/hexane), yielding 29.6 g of N-(2-hydroxyethyl)-9-octadecenyl succinimide (yield: 75.3%).

Source