Reaction #1340577

Reaction equation

octadecyl succinic anhydride

ethanolamine

→

N-(2-hydroxyethyl)octadecyl succinimide

Yield 54.0%

Conditions

Workup

1. 1
   OtherA 50 mL reaction flask
2. 2
   Otherthe resulting mixture was reacted at 160° C. for 4 hours under continuous nitrogen purging and with vigorous stirring
3. 3
   OtherThe reaction product was purified by silica gel column chromatography (mobile phase: ethyl acetate/hexane)

Procedure

A 50 mL reaction flask was charged with 17.6 g of octadecyl succinic anhydride (manufactured by Tokyo Chemical Industry Co., Ltd.) and 3.1 g of ethanolamine (manufactured by Tokyo Chemical Industry Co., Ltd.), and the resulting mixture was reacted at 160° C. for 4 hours under continuous nitrogen purging and with vigorous stirring. The reaction product was purified by silica gel column chromatography (mobile phase: ethyl acetate/hexane), yielding 10.6 g of N-(2-hydroxyethyl)octadecyl succinimide (yield: 54%).

Source