Reaction #1340567

Reaction equation

dibenzo[f,h]quinoxaline

hexane

n-butyllithium

3-bromofluorobenzene

→

2-(3-Fluorophenyl)-dibenzo[f,h]quinoxaline

Yield 23.0%

Solvents

dichloromethane

Water

tetrahydrofuran

Conditions

Workup

1. 1
   TemperatureThe mixture was heated to room temperature
2. 2
   workup.STIRRINGstirred for 12 hours with the temperature
3. 3
   Temperaturemaintained at room temperature
4. 4
   Extractionwas extracted
5. 5
   DryingThe obtained organic layer was dried with anhydrous magnesium sulfate
6. 6
   OtherThe solution obtained by the drying
7. 7
   Filtrationwas filtrated
8. 8
   workup.DISTILLATIONThe solvent of this solution was distilled off
9. 9
   Otherby recrystallization with ethanol
10. 10
    Otherwas obtained (a light-orange powder, yield: 23%)
11. 11
    OtherSynthesis scheme of Step 1

Procedure

First, under a nitrogen atmosphere, 27.5 mL (1.58 mol/L) of a hexane solution of n-butyllithium was dripped into a mixed solution of 6.87 g of 3-bromofluorobenzene and 40 mL of tetrahydrofuran at −78° C. Then, with the temperature maintained at −78° C., the mixture was stirred for 2 hours. To the obtained solution was added 7.54 g of dibenzo[f,h]quinoxaline in five additions at −78° C. The mixture was heated to room temperature,and stirred for 12 hours with the temperature maintained at room temperature. Water was added to this mixture and dichloromethane was used as an extraction solvent, so that an organic layer was extracted. The obtained organic layer was dried with anhydrous magnesium sulfate. The solution obtained by the drying was filtrated. The solvent of this solution was distilled off, and then, by recrystallization with ethanol, the organometallic complex of the present invention, Hdbq-3FP, which was the target substance, was obtained (a light-orange powder, yield: 23%). Synthesis scheme of Step 1 is shown in (a-2) below.

Source