Reaction #1282

Reaction equation

triethylamine

benzylchloroformate

(S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

ethanol

→

(S)-1,3,4,5-Tetrahydro-4-[[(phenylmethoxy)carbonyl]amino]-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

Solvents

ethyl acetate

ethyl acetate

toluene

hydrazine hydrate

Conditions

Workup

1. 1
   Filtrationfiltered
2. 2
   Otherfiltrate evaporated to dryness
3. 3
   Otheragain evaporated to dryness
4. 4
   Otherplaced in an ice bath
5. 5
   Otherthe mixture was partitioned between ethyl acetate-5% potassium bisulfate
6. 6
   WashThe organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions
7. 7
   Dryingdried (sodium sulfate)
8. 8
   Otherevaporated to dryness
9. 9
   OtherPurification of the crude product by flash chromatography on silica gel (Whatmann LPS-1)
10. 10
    Washeluting with ethyl acetate:hexane (1:2)
11. 11
    Othergave 1.0747 g
12. 12
    OtherA sample crystallized from hexane
13. 13
    Other[α]D =+87.2° (C=0.53, chloroform)

Procedure

A solution of (S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester (1.67 g., 4.26 mmol.) in 1.0M hydrazine hydrate in ethanol (9.0 ml., 9.0 mmol.) was stirred at room temperature under argon for 36 hours. The mixture was diluted with an equal volume of ethyl acetate, filtered and filtrate evaporated to dryness. The residue was taken up in toluene and again evaporated to dryness. The colorless, semi-solid residue (1.81 g.) was taken up in dry methylene chloride (20 ml.), placed in an ice bath and treated successively with triethylamine (0.80 ml., 5.8 mmol.) and benzylchloroformate (0.77 ml., 5.4 mmol.). After stirring at 0° C. for 2 hours, the mixture was partitioned between ethyl acetate-5% potassium bisulfate. The organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions, dried (sodium sulfate), and evaporated to dryness. Purification of the crude product by flash chromatography on silica gel (Whatmann LPS-1) eluting with ethyl acetate:hexane (1:2) gave 1.0747 g. of product as a colorless foam; Rf =0.52 (ethyl acetate:toluene, 3:7). A sample crystallized from hexane had m.p. 80°-82° C.; [α]D =+87.2° (C=0.53, chloroform).

Source