Reaction #1269839

Reaction equation

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

Solvents

piperidine

dimethylformamide

Conditions

Workup

1. 1
   ConcentrationThe reaction mixture is concentrated under vacuum, water
2. 2
   workup.ADDITIONis added to the residue
3. 3
   Extractionthe product is extracted with ethyl acetate
4. 4
   OtherThe crude product is purified by conversion into its hydrochloride salt

Procedure

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) is dissolved in 20% piperidine in dimethylformamide at 0° C. The solution is continued stifling for 1 h. The reaction mixture is concentrated under vacuum, water is added to the residue, and the product is extracted with ethyl acetate. The crude product is purified by conversion into its hydrochloride salt.

Source