Reaction #1265407

Reaction equation

phosphorus oxychloride

1,2,4-triazole

compound

2-acetylamino-6-(3,4-dimethoxyphenyl)pterine

→

title compound

Yield 80.0%

2-acetylamino-4-(1,2,4-triazolyl)-6-(3,4-dimethoxyphenyl)pteridine

Yield 80.0%

Solvents

pyridine

Conditions

Workup

1. 1
   FiltrationThe precipitate was filtered off
2. 2
   Washwashed with pyridine, toluene and diethyl ether
3. 3
   DryingThe resulting solid was dried over P2O5 under vacuum

Procedure

To a solution of phosphorus oxychloride (1.68 ml, 18 mmoles) and 1,2,4-triazole (4.96 g, 72 mmoles) in dry pyridine (110 ml) was added the compound of example 102 (2.45 g, 7.18 mmoles). The suspension was stirred at room temperature for 4 hours. The precipitate was filtered off, washed with pyridine, toluene and diethyl ether. The resulting solid was dried over P2O5 under vacuum, providing the title compound as a yellow powder (2 g, yield: 80%) which afforded the following mass spectrum: 392 ([M+H]+, 100).

Source