Reaction #1265399

Reaction equation

sodium

4-chloro-2,6-diaminopyrimidine

ethanol

→

title compound

Yield 72.0%

2,6-diamino-4-ethoxy-pyrimidine

Yield 72.0%

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was cooled down
2. 2
   Filtrationthe precipitated sodium chloride was filtered off
3. 3
   ConcentrationThe filtrate was concentrated
4. 4
   Otherprecipitated from ethanol (two times)

Procedure

To a solution of sodium (1.05 g) in ethanol (50 ml) was added 4-chloro-2,6-diaminopyrimidine (6 g, 41.4 mmoles). The resulting solution was heated in a reactor for 6 hours at 160° C. The reaction mixture was cooled down and the precipitated sodium chloride was filtered off. The filtrate was concentrated and precipitated from ethanol (two times), affording the pure title compound as a white solid (4.53 g, 72% yield). The spectral data are identical to those described e.g. by W. Pfleiderer et al. in Chem. Ber. (1961) 94, 12.

Source