Reaction #1265367

ord-dfb80ab567c9463587071e3d25f3bfa6

Reaction equation

c1ccc2[nH]cnc2c1
benzimidazole
COc1ccc(C(=O)OCCCl)cc1
2-chloroethyl 4-methoxybenzoate
COc1ccc(C(=O)OCCn2c(-c3ccccc3)nc3ccccc32)cc1
2-(2-phenyl-1H-benzimidazol-1-yl)ethyl 4-methoxybenzoate
Yield 71.0%

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe procedure of Synthesis Example 10

Procedure

The procedure of Synthesis Example 10 was repeated except that benzimidazole was used instead of the 1-aza-18-crown-6, and 2-chloroethyl 4-methoxybenzoate was used instead of the 2-chloroethyl benzoate, to give 2-(2-phenyl-1H-benzimidazol-1-yl)ethyl 4-methoxybenzoate in a yield of 71%.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07276324B2uspto-grants-2007_10