Reaction #1265365

Reaction equation

1-aza-18-crown-6

2-chloroethyl benzoate

potassium carbonate

→

2-(1,4,7,10,13-pentaoxa-16-azacyclo-octadecan-16-yl)ethyl benzoate

Solvents

N,N-dimethylformamide

Conditions

Workup

1. 1
   OtherThe reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography

Procedure

A mixture of 26.3 g of 1-aza-18-crown-6, 19.9 g of 2-chloroethyl benzoate, 21.0 g of potassium carbonate, and 60 g of N,N-dimethylformamide was stirred for 10 hours at 80° C. The reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography. There was obtained 320 g of 2-(1,4,7,10,13-pentaoxa-16-azacyclo-octadecan-16-yl)ethyl benzoate (yield 75%).

Source