Reaction #1256734

Reaction equation

[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile

di-terbutyl carbonate

Sodium borohydride

→

tert-butyl {2-[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]ethyl}carbamate

Solvents

methanol

Conditions

Workup

1. 1
   workup.ADDITIONis added portionwise to the reaction mixture
2. 2
   Otheris allowed to room temperature

Procedure

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

Source