Reaction #11721

Reaction equation

chloroacetyl chloride

(3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine

triethylamine

→

title compound

2-Chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

Solvents

dichloromethane

dichloromethane

Conditions

Workup

1. 1
   Temperatureto warm to ambient temperature
2. 2
   Washwashed with 10% citric acid
3. 3
   OtherThe organic layer was separated
4. 4
   Dryingdried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Concentrationconcentrated in vacuo

Procedure

To a solution of (3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine (3 g, 14.4 mmol) in dichloromethane (40 mL) was added triethylamine (2.0 mL, 14.4 mmol). The reaction was cooled to 0° C. and chloroacetyl chloride was added (1.1 mL, 14.4 mmol). The reaction was allowed to warm to ambient temperature and stirred for 2 hours. The reaction is diluted with dichloromethane and washed with 10% citric acid. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (3.9 g).

Source