Reaction #11647

Reaction equation

4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine hydrochloride

5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one

Et3N

→

compound

Yield 49.3%

5-Chloro-3-{[4-(1-methyl-piperidin-3-ylmethoxy)-phenylamino]-methylene}-1,3-dihydro-indol-2-one

Yield 49.3%

Conditions

Workup

1. 1
   Otherare reacted

Procedure

In a manner similar to that described in Example 231, 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine hydrochloride (158 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (100 mg, 0.51 mmol, 1 equiv.) with the addition of anhydrous Et3N (2.11 equiv.) are reacted to give the named compound as a yellow solid (100 mg, 49%).

Source