Reaction #1159062

Reaction equation

(3S)-3-Amino-1-chloro-4-phenyl-2-butanone hydrochloride

methyl chloroformate

sodium hydrogencarbonate

→

(3S)-3-methoxycarbonylamino-1-chloro-4-phenyl-2-butanone

Yield 78.0%

Solvents

water

toluene

Conditions

Workup

1. 1
   Otherthe reaction
2. 2
   ExtractionAfter the extraction with toluene twice
3. 3
   OtherThe solvents were evaporated under reduced pressure
4. 4
   workup.ADDITIONn-Hexane and 2-propanol were added to the residue
5. 5
   TemperatureThe obtained mixture was heated to 50° C.
6. 6
   Otherto obtain a homogeneous solution, which
7. 7
   Temperaturewas cooled to 10° C.
8. 8
   Otherto form crystals
9. 9
   FiltrationThe crystals were taken by the filtration
10. 10
    Washwashed with cold 2-propanol (6 ml)
11. 11
    Otherdried

Procedure

(3S)-3-Amino-1-chloro-4-phenyl-2-butanone hydrochloride (2.0 g) was dissolved in water (34 ml). A solution (50 ml) of methyl chloroformate (0.858 ml) in toluene was added to the obtained solution. Further, an aqueous solution (15 ml) of sodium hydrogencarbonate (1.44 g) was added dropwise to the obtained mixture. They were stirred at room temperature for 1 hour to conduct the reaction. After the extraction with toluene twice and with ethyl acetate twice, the organic layers were combined together. The solvents were evaporated under reduced pressure. n-Hexane and 2-propanol were added to the residue. The obtained mixture was heated to 50° C. to obtain a homogeneous solution, which was cooled to 10° C. to form crystals. The crystals were taken by the filtration, washed with cold 2-propanol (6 ml) and then dried to obtain (3S)-3-methoxycarbonylamino-1-chloro-4-phenyl-2-butanone (1.70 g) in a yield of 78%.

Source