Reaction #1148621

Reaction equation

4-chloro-3-methoxy-2-methylpyridine

hydrogen peroxide water

→

4-chloro-3-methoxy-2-methylpyridine N-oxide

Solvents

acetic acid

Conditions

Workup

1. 1
   workup.DISTILLATIONthe reaction solution was distilled off under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in chloroform
3. 3
   Washwashed with saturated sodium bicarbonate solution, and saturated salt water
4. 4
   Dryingdried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedure

36.98 g of 4-chloro-3-methoxy-2-methylpyridine (V) was dissolved in 685 ml of acetic acid and 92 ml of hydrogen peroxide water was added thereto and the resulting mixture was heated at 90° C. for 24 hours, and thereafter, the reaction solution was distilled off under reduced pressure. The resulting residue was dissolved in chloroform and washed with saturated sodium bicarbonate solution, and saturated salt water, and thereafter, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 37.64 g of 4-chloro-3-methoxy-2-methylpyridine N-oxide (VI).

Source