Reaction #1144428

Reaction equation

1-(methoxymethyl)-6-phenylthiothymine

→

target compound

Yield 28.1%

6-phenylthiothymine

Yield 28.1%

Solvents

hydrochloric acid

Conditions

Workup

1. 1
   Otherto react for 2 hours at 80° C
2. 2
   ConcentrationThe reaction mixture was concentrated under reduced pressure
3. 3
   Othercrystallized from ethanol

Procedure

To 100 ml of concentrated hydrochloric acid, 17.2 g (62 mmole) of 1-(methoxymethyl)-6-phenylthiothymine was added and allowed to react for 2 hours at 80° C. The reaction mixture was concentrated under reduced pressure and crystallized from ethanol to obtain 3.8 g of the target compound (Yield: 26%).

Source