Reaction #1136

Reaction equation

pyridine

fumaric acid

amine

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine

→

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

Yield 70.0%

Solvents

methanol

Conditions

Workup

1. 1
   OtherAfter 30 minutes the solvent was removed in vacuo

Procedure

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.

Source