Reaction #1135841

Reaction equation

methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate

Yield 67.7%

Solvents

toluene

Conditions

Workup

1. 1
   Concentrationconcentrated
2. 2
   OtherThe residue was purified by biotage column chromatography

Procedure

To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)

Source