Reaction #1135838
ord-f55947f3bab349708f5c9b9c95740c9e
Reaction equation
1-fluoro-2-nitrobenzene
cyclopropyl amine
→
N-cyclopropyl-2-nitroaniline
Yield 96.2%
Reagents
None
Solvents
Conditions
Temperature
80°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Concentrationconcentrated
- 2OtherThe residue was purified by biotage column chromatography
Procedure
To a solution of 1-fluoro-2-nitrobenzene (0.50 g, 3.5 mmol) in ethanol was added cyclopropyl amine (0.60 g, 10.5 mmol). The solution was heated to 80° C. overnight and concentrated. The residue was purified by biotage column chromatography to give N-cyclopropyl-2-nitroaniline (0.60 g)