Reaction #1135831

Reaction equation

methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate

Yield 84.3%

Solvents

toluene

Conditions

Workup

1. 1
   Concentrationconcentrated
2. 2
   OtherThe residue was purified by biotage column chromatography

Procedure

To a solution of methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate (140 mg, 0.395 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate (113 mg)

Source