Reaction #1135817

Reaction equation

3-trifluoromethyl-2-methylbenzoic acid

oxalyl dichloride

N,N-dimethylformamide

→

3-trifluoromethyl-2-methylbenzoic acid chloride

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   OtherThe reaction mixtures
2. 2
   Concentrationwere concentrated under reduced pressure

Procedure

A mixture of 3-trifluoromethyl-2-methylbenzoic acid 5.00 g, oxalyl dichloride 3.42 g, N,N-dimethylformamide about 50 mg and tetrahydrofuran 200 mL was stirred at 25° C. for one hour. The reaction mixtures were concentrated under reduced pressure to give 3-trifluoromethyl-2-methylbenzoic acid chloride.

Source