Reaction #1135814

Reaction equation

3-ethoxy-2-methylaniline

triphosgene

→

1-ethoxy-3-isocyanato-2-methylbenzene

Solvents

toluene

Conditions

Workup

1. 1
   Temperaturewith heating
2. 2
   Temperaturereflux for four hours
3. 3
   ConcentrationThe mixtures were concentrated under reduced pressure

Procedure

At room temperature, to a mixture of 3-ethoxy-2-methylaniline 33.0 g and toluene 400 mL was added triphosgene 25 g, and the resulting mixtures were stirred with heating reflux for four hours. The mixtures were concentrated under reduced pressure to give 1-ethoxy-3-isocyanato-2-methylbenzene 37.2 g.

Source