Reaction #1130805

ord-db7850f08cce4375a4e58fc65d1b8774

Reaction equation

Clc1nc(N2CCOCC2)c2nc(CBr)ccc2n1
4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine
Clc1nc(N2CCOCC2)c2nc(CBr)ccc2n1
4-(6-(bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine
CC1(C)CCNC1
3,3-dimethylpyrrolidine
CC1(C)CCN(Cc2ccc3nc(Cl)nc(N4CCOCC4)c3n2)C1
4-(2-chloro-6-((3,3-dimethylpyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.225 g) was reacted with 3,3-dimethylpyrrolidine via General Procedure B to afford quantitative yield of 4-(2-chloro-6-((3,3-dimethylpyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08563540B2uspto-grants-2013_10