Reaction #1106684

Reaction equation

potassium phthalimide

water

DMF

→

(2S)-2-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-isoindole-1,3-dione

Conditions

Workup

1. 1
   Temperatureheated
2. 2
   Temperatureto reflux for 1 h
3. 3
   FiltrationWhite solid was filtered
4. 4
   Washthe solid was washed several times with water, 2% NaOH, and water again
5. 5
   Otherdry

Procedure

The white solid was combined with potassium phthalimide (14.4 g, 78 mmol) in DMF (250 mL) and heated to reflux for 1 h, cooled to room temperature and poured into vigorously stirring water (1.5 L) and stirred 30 min. White solid was filtered and the solid was washed several times with water, 2% NaOH, and water again and let air dry to yield a (2S)-2-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-isoindole-1,3-dione as white powdery solid.

Source